THE SCIENCE OF BEING
In my sophomore year of high school, Mrs. Carolyn Kelley taught us that lichen is actually a combination of a fungus and cyanobacteria, a type of algae. Underneath a microscope, the pale, uninteresting lichen that I had known all my life became a complex tangle of fungi and vibrant, blue-green spheres; it became beautiful. Since that discovery I have been fascinated by biology and uncovering how living things work.
This segment, posted once monthly, is meant to shed light on those things that make us human, on the scientific explanations for creative and emotional experiences. For most people, and certainly for most artists, science is written in an inaccessible language of seventeen syllable Latinglish terminology that may as well be the German Enigma code. It’s my job to dig through all the ridiculous terminology, over-labeled diagrams, and incomprehensible bio-babble to figure out what makes us tick, as humans and as artists, and to lay it out in plain English.
In choosing a topic for the first ever post, empathy seemed most appropriate because it is an experience that is essential to human interaction and relationships. Traditionally, and especially amongst artists, empathy is discussed and understood strictly in an emotional sense; like love, empathy is perceived as an intangible feeling, a romanticized notion that science cannot explain.
But science can explain.
EMPATHY
Noun. Understanding and entering into another’s feelings; identification with and understanding of another’s situation, feelings, and/or motives.
If you’ve ever burst into tears in the middle of a Disney movie or winced while watching people eat spiders on Fear Factor, you’ve felt empathy. If you’ve ever seen sadness in a friend’s eyes, or sheer joy in their smile, or the glow of excitement in their cheeks, you’ve felt empathy. The experience of empathy creates a universal bond between human beings that transcends language, culture, and community, giving us the means to know and bond with other people. Without empathy, we would never be able to love, laugh, or create art; we would never be able to explain our emotions to others, or understand how another person is feeling. Without empathy every human being would be an island: isolated, inaccessible, and endlessly alone.
All mammals display some degree of empathy. This inherent experience is a prerequisite for understanding the experiences of other people, for bonding with those people, for loving those people. For artists, empathy is an essential skill that allows us to create and imagine characters worlds apart from ourselves, to construct the emotions and the motives of a consciousness different from our own; empathy is an inherent part of our imaginations.
Although the origins of empathy in humans and in mammals are still being explored, the current theory is that the roots of empathy lay in maternal instinct. According to Dr. Frans de Waal, who is searching for the evolutionary steps to human empathy in chimpanzees, our closest relatives, “mammals need a mechanism like this because a female needs to be very sensitive to emotional signals that come from offspring”[1]. In theory, the necessity of females to catch the slightest emotional changes of their offspring has allowed all humans to be sensitive to the emotions of others, even so far as to have an automatic, neurological reflex that aids in this understanding.
In April of 1996, three neuroscientists working at the Università di Parma in Italy discovered a bundle of cells in the premotor cortex of a macaque monkey that were active both when the monkey performs an action, and when the monkey observed one of its fellows performing an action[2][3]. The trio termed these cells mirror neurons.
Scientists have since proved the existence of a mirror neuron system in humans. The human brain has a much more extensive and complex network of mirror neurons, reflecting not only the actions of others, but sensation and emotion as well[4]. This is the “neural mechanism by which the actions, intentions, and emotions of other people can be automatically understood”[5].
When the human body experiences pain, several different regions of the brain are activated, allowing you to understand and experience the sensation[6]. These regions can be separated into two primary groups based on function; one group is responsible for the sensation of pain, while the other is responsible for determining the origin of that sensation. The first group allows us to feel pain; these parts of the brain receive and interpret signals from nerves in the affected region and translate those messages into a physical sensation of pain (dull, sharp, pinching, burning, etc). The second group locates the pain; these regions work to determine the specific location of pain on the body, and work to determine what is causing the sensation of pain[7].
This first group is part of the mirror neuron system in human beings. When you see another person in physical pain, those neurons are activated, allowing you to experience something of the pain you are observing. These same neurons will also fire when you attempt to imagine yourself or another person in pain.
Imagine, for instance, that you have just shut your hand in a door. Even if you have never experienced this particular painful accident, you can still imagine the heavy, crushing weight of the door, the sharp line of the edge on the back of your hand. At this moment, neurons in half a dozen regions of your brain are active, allowing you to understand that (imagined) sensation[8].
But what if you have never experienced pain? Congenital insensitivity to pain (CPI) is an extremely rare genetic condition that eliminates a person’s ability to experience pain; people who suffer from CPI cannot and have never felt physical pain[9]. However, studies have shown that people with CPI can still empathize with those who do. In a study conducted earlier this year at the Pitié-Salpêtrière Hospital in Paris, Dr. Nicholas Danziger asked patients with CPI and control subjects (who experience pain normally) to imagine the feelings of various individuals in photographs. These photographs showed either “body parts in painful situations,” (a hand in a door, perhaps?), or “facial expressions of pain”[10]. Although patients with CPI rated the pain experiences of the ‘painful situation’ photographs as far less intense (than control subjects), they were able to infer pain as accurately as control subjects[11].
Based on brain activity, Danziger theorized that patients with CPI may have been relating observed physical pain to emotional pain they had experienced. Scans of their brains during the study showed activity in regions of the brain involved in “formulating emotional perspectives”[12]. This ability to imagine and empathize with pain or situations we have never experienced is essential to human interaction.
Among many other symptoms, children with Autism Spectrum Disorder (ASD) are unable to empathize; while observing others, children with ASD will not be able to determine if someone is happy or sad without those emotions being specifically and clearly expressed verbally[13]. Currently, scientists are testing the theory that an impaired or non-functioning mirror neuron system is what limits or eliminates empathy in ASD patients. At the University of Tokyo in 2007, a group of scientists used sympathetic yawning to measure the empathetic response of children with ASD[13]. Sympathetic yawning – ‘catching’ a yawn from another person – is a function of the mirror neuron system, and ultimately an empathetic act[13]. During the study, children with ASD and “typically developing” (TD) children were isolated and asked to count the female faces in a video (to ensure/measure the amount of attention paid). The video consisted of six clips of individuals yawning, and six clips of people opening and closing their mouths (‘control’ clips); between each clip of yawning or mouth opening, a silent cartoon played to hold their attention[13]. The results showed that TD children yawned far more during the clips of people yawning than during the control clips, as expected, displaying sympathetic yawning[13]. Children with ASD, however, yawned equally during both sets of clips, and yawned less than TD children [13].
Scientists suspected an impaired or non-functioning mirror neuron system might also play a role in aggressive conduct disorder (CD), “a behavioral and emotional disorder of childhood and adolescence”[14]. Children with CD “act inappropriately, infringe on the rights of others, and violate the behavioral expectations of others”[14]. CD is often found in children/adolescents who are verbally or physically abusive to other children, and is associated with childhood bullying. Expecting to find a lack of empathetic response, Dr. Jean Decety conducted a study at the University of Chicago earlier this year in which children with and without CD watched video of individuals being injured, accidentally and purposefully[14]. However, fMRI scans (functional MRI, an imaging technique used to view brain activity) showed that children with CD had more extensive activation in the mirror neuron system[14]. Even more surprising, the scans revealed active neurons in the amygdala and the central striatum, areas associated with positive reinforcement and reward[14]. For those without CD, seeing someone in pain is “unpleasant, it’s negative,” Dr. Decety explains, “And for the bullies [children with CD], it’s not unpleasant. It’s really pleasant, it’s positive, it’s even rewarding”[15].
SOURCES:
01: http://online.wsj.com/article/SB125382470366238705.html
02: http://brain.oxfordjournals.org/cgi/content/abstract/119/2/593
03: http://www.livescience.com/health/050427_mind_readers.html
04: http://www.livescience.com/health/050427_mind_readers.html
05: http://www.sciencedaily.com/releases/2007/05/070504121241.htm#
06: http://www.physorg.com/news152341493.html
07: [link dead - currently searching for a new source]
08: http://magazine.uchicago.edu/0604/features/emotion.shtml
09: http://www.sciencenews.org/view/generic/id/40302/title/I_feel_your_pain,_even_though_I_cant_feel_mine
10: http://www.physorg.com/news152341493.html
11: http://brain.oxfordjournals.org/cgi/content/abstract/129/9/2494
12: http://www.sciencenews.org/view/generic/id/40302/title/I_feel_your_pain,_even_though_I_cant_feel_mine
13: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391210/
14: http://tinyurl.com/atypicalempathicresponsesstudy
15: http://www.earthsky.org/interviewpost/human-world/jean-decety-says-bullies-brains-might-work-differently